List of Trials

Below you find the references to trials investigating the efficacy of interventions targeting the prevention of prevention in various settings (many of these are included in the last systematic review on this subject).

Universal Prevention

Sheffield, J.K., Spence, S.H., Rapee, R.M., Kowalenko, N., Wignall, A., Davis, A. & McLoone, J. (2006). Evaluation of universal, indicated, and combined cognitive-behavioral approaches to the prevention of depression among adolescents. Journal of Consulting and Clinical Psychology, 74, 66-79.

Spence, S., Sheffield, J. & Donovan, C. (2003). Preventing adolescent depression: An evaluation of the Problem Solving for Life Program. Journal of Consulting and Clinical Psychology, 71, 3-13

Selective Prevention

Austin MP, Frilingos M, Lumley J, Hadzi-Pavlovic D, Roncolato W, et al. (2008). Brief antenatal cognitive behaviour therapy group intervention for the prevention of postnatal depression and anxiety: a randomised controlled trial. J. Affect. Disord. 105:35–44

Brugha, T.S., Wheatly, S., Taub, N.A., Culverwell, A., Freidman, T., Kirwan, P., Jones, D.R. & Shapiro, D.A. (2000). Pragmatic randomized trial of antenatal intervention to prevent post-natal depression by reducing psychosocial risk factors. Psychological Medicine, 30, 1273-1281.

Compas, B. E., Forehand, R., Keller, G., Champion, J. E., Rakow, A., Reeslund, K. L., … & Merchant, M. J. (2009). Randomized controlled trial of a family cognitive-behavioral preventive intervention for children of depressed parents. Journal of consulting and clinical psychology, 77(6), 1007.

Dennis CL, Hodnett E, Kenton L,Weston J, Zupancic J, et al. (2009 ). Effect of peer support on prevention of postnatal depression among high risk women: multisite randomised controlled trial. Br.Med. J. 338:a3064

Elliott, S.A., Leverton, T.J., Sanjack, M., Turner, H., Cowmeadow, P., Hopkins, J. & Bushnell, D. (2000). Promoting mental health after childbirth: a controlled trial of primary prevention of postnatal depression. British Journal of Clinical Psychology, 39, 223-241

García-Campayo, J., Arevalo, E., Claraco, L. M., Alda, M., & del Hoyo, Y. L. (2010). A prevention programme for somatoform disorders is effective for affective disorders. Journal of affective disorders, 122(1), 124-132.

Hagan, R., Evans, S.F. & Pope, S. (2004). Preventing postnatal depression in mothers of very preterm infants: a randomised controlled trial. BJOG, 111, 641-647

Imamura, K., Kawakami, N., Furukawa, T. A., Matsuyama, Y., Shimazu, A., Umanodan, R., … & Kasai, K. (2015). Does Internet-based cognitive behavioral therapy (iCBT) prevent major depressive episode for workers? A 12-month follow-up of a randomized controlled trial. Psychological medicine, 45(09), 1907-1917.

Jimenez DE, Reynolds CF 3rd, Alegría M, Harvey P, Bartels SJ (2015). The Happy Older Latinos are Active (HOLA) health promotion and prevention study: study protocol for a pilot randomized controlled trial. Trials. 2015 Dec 18;16:579. doi: 10.1186/s13063-015-1113-3.

Joling, K. J., van Marwijk, H. W., Smit, F., van der Horst, H. E., Scheltens, P., van de Ven, P. M., … & van Hout, H. P. (2012). Does a family meetings intervention prevent depression and anxiety in family caregivers of dementia patients? A randomized trial. PloS one, 7(1), e30936.

Lewis, G., Araya, R., Tang, W. K., Mak, W. W. S., Cheung, F. M. C., Mercer, S. W., … & Lam, A. T. (2014). Prevention of anxiety and depression in Chinese: A randomized clinical trial testing the effectiveness of a stepped care program in primary care. Journal of affective disorders, 169, 212-220.

Martinovic, Z., Simonovic, P. & Djokic, R. (2006). Preventing depression in adolescents with epilepsy. Epilepsy and Behavior, 9, 619-624

Muñoz, R.F., Ying, Y.W., Bernal, G., Perez-Stable, E.J., Sorensen, J.L., Hargreaves, W.A., Miranda, J. & Miller, L.S. (1995). Prevention of depression with primary care patients: a randomized controlled trial. American Journal of Community Psychology, 23, 199-222

Priest, S., Henderson, J., Evans, S. & Hagan, R. (2003). Stress debriefing after childbirth: a randomized controlled trial. Medical Journal of Australia, 178, 542–545.

Robinson, R.G. (2003). Poststroke depression: prevalence, diagnosis, treatment, and disease progression. Biological Psychiatry, 54, 376-387.

Rohde, P., Stice, E., Shaw, H., & Gau, J. M. (2015). Effectiveness trial of an indicated cognitive–behavioral group adolescent depression prevention program versus bibliotherapy and brochure control at 1-and 2-year follow-up. Journal of consulting and clinical psychology, 83(4), 736.

Rovner, B.W., Casten, R.J., Hegel, M.T., Leiby, B.E. & Tasman, W.S. (2007).Preventing depression in age-related macular degeneration. Archives of General Psychiatry, 64, 886-892.
Seligman, M.E.P., Schulman, P., DeRubeis, R.J., Hollon, S.D. (1999). The prevention of depression and anxiety. Prevention & Treatment, 2, np.
Seligman MEP, Schulman P, Tryon AM. 2007. Group prevention of depression and anxiety symptoms. Behav. Res. Ther. 45:1111–26
Silverstein M, Diaz-Linhart Y, Cabral H, Beardslee W, Hegel M, Haile W, Sander J, Patts G, Feinberg E. Efficacy of a Maternal Depression Prevention Strategy in Head Start: A Randomized Clinical Trial. JAMA Psychiatry. Published online June 14, 2017.
Stice E, Rohde P, Seeley JR, Gau JM. 2008. Brief cognitive-behavioral depression prevention program for high-risk adolescents outperforms two alternative interventions: a randomized efficacy trial. J. Consult. Clin. Psychol. 76:595–606

Young JF, Benas JS, Schueler CM, Gallop R, Gillham JE, Mufson L. (2016). A Randomized Depression Prevention Trial Comparing Interpersonal Psychotherapy–Adolescent Skills Training to Group Counseling in Schools. Prev Sci Apr;17(3):314-24

Zlotnick C, Johnson SL, Miller IW, Pearlstein T, Howard M: Postpartum depression in women receiving public assistance: pilot study of an interpersonal-therapy-oriented group intervention. Am J Psychiatry 2001; 158: 638-640

Zlotnick C, Miller IW, Pearlstein T, Howard M, Sweeney P: A preventive intervention for pregnant women on public assistance at risk for postpartum depression. Am J Psychiatry 2006; 163: 1443-1445.

Zlotnick, C., Capezza, N. M., & Parker, D. (2011). An interpersonally based intervention for low-income pregnant women with intimate partner violence: a pilot study. Archives of women’s mental health, 14(1), 55-65.

Indicated Prevention

Allart-van Dam, E., Hosman, C.M., Hoogduin, C.A. & Schaap, C.P. (2007). Prevention of depression in subclinically depressed adults: follow-up effects on the ‘Coping with Depression’ course. Journal of Affective Disorders, 97, 219-228.

Arnarson, E. & Craighead, W.E. (2009). Prevention of depression among Icelandic adolescents. Behav. Res. Ther. 47:577–85

Bot, M., Pouwer, F., Ormel, J., Slaets, J. P., & De Jonge, P. (2010). Predictors of incident major depression in diabetic outpatients with subthreshold depression. Diabetic Medicine, 27(11), 1295-1301.

Brent DA, Brunwasser SM, Hollon SD, Weersing VR, Clarke GN, Dickerson JF, Beardslee WR, Gladstone TR, Porta G, Lynch FL, Iyengar S, Garber J. (2015). Effect of a Cognitive-Behavioral Prevention Program on Depression 6 Years After Implementation Among At-Risk Adolescents: A Randomized Clinical Trial.JAMA Psychiatry. 2015 Nov;72(11):1110-8. doi: 10.1001/jamapsychiatry.2015.1559.

Buntrock C, Ebert DD, Lehr D, Smit F, Riper H, Berking M, Cuijpers P. (2016). Effect of a Web-Based Guided Self-help Intervention for Prevention of Major Depression in Adults With Subthreshold Depression: A Randomized Clinical Trial. JAMA. 2016 May 3;315(17):1854-63. doi: 10.1001/jama.2016.4326.

Christensen H, Batterham PJ, Gosling JA, Ritterband LM, Griffiths KM, Thorndike FP, et al. Effectiveness of an online insomnia program (SHUTi) for prevention of depressive episodes (the GoodNight Study): a randomised controlled trial. The Lancet Psychiatry [Internet]. 2016 Apr [cited 2017 Feb 21];3(4):333–41.

Clarke, G.N., Hawkins, W., Murphy, M., Sheeber, L.B., Lewinsohn, P.M. & Seeley, J.R. (1995). Targeted prevention of unipolar depressive disorder in an at-risk sample of high school adolescents: a randomized trial of a group cognitive intervention. Journal of the American Academy of Child and Adolescent Psychiatry, 34, 312-321

Clarke, G.N., Hornbrook, M., Lynch, F., Polen, M., Gale, J., Beardslee, W., O’Connor, E. & Seeley, J. (2001).A randomized trial of a group cognitive intervention for preventing depression in adolescent offspring of depressed parents. Archives of General Psychiatry, 58, 1127-1134.

De Jonge, P., Hadj, F. B., Boffa, D., Zdrojewski, C., Dorogi, Y., So, A., … & Stiefel, F. (2009). Prevention of major depression in complex medically ill patients: preliminary results from a randomized, controlled trial. Psychosomatics, 50(3), 227-233.

Garber J, Clarke GN,Weersing VR, Beardslee WR, Brent DA, et al. 2009. Prevention of depression in at-risk adolescents: a randomized controlled trial. JAMA 301:2215–24

Gillham, J.E., Hamilton, J., Freres, D.R., Patton, K. & Gallop, R. (2006). Preventing depression among early adolescents in the primary care setting: a randomized controlled study of the Penn Resiliency Program. Journal of Abnormal Child Psychology, 34, 203-219

Konnert C, Dobson K, Stelmach L. 2009. The prevention of depression in nursing home residents: a randomized clinical trial of cognitive-behavioral therapy. Aging Ment. Health 13:288–99

Lara MA, Navarro C, Navarrete L. (2010). Outcome results of a psycho-educational intervention in pregnancy to prevent PPD: a randomized control trial. J Affect Disord. 2010 Apr;122(1-2):109-17.

Müller S, Rohde P, Gau JM, Stice E. (2015). Moderators of the effects of indicated group and bibliotherapy cognitive behavioral depression prevention programs on adolescents’ depressive symptoms and depressive disorder onset. Behav Res Ther. 2015 Dec;75:1-10. doi: 10.1016/j.brat.2015.10.002.

Muñoz, R.F., Le, H.N., Ippen, C.G., Diaz, M.A., Urizar, Jr, G.G., Soto, J., Mendelson, T., Delucchi, K. & Lieberman, A.F. (2007). Prevention of postpartum depression in low-income women: Development of the Mamas y Bebes/Mothers and Babies course. Cognitive Behavior Practice, 14, 70-83.

Otero, P., Smit, F., Cuijpers, P., Torres, A., Blanco, V., & Vázquez, F. L. (2015). Long-term efficacy of indicated prevention of depression in non-professional caregivers: randomized controlled trial. Psychological medicine, 45(07), 1401-1412.

Reynolds III, C. F., Thomas, S. B., Morse, J. Q., Anderson, S. J., Albert, S., Dew, M. A., … & Stack, J. A. (2014). Early intervention to preempt major depression among older black and white adults. Psychiatric services, 65(6), 765-773.

Sánchez-Villegas, A., Martínez-González, M. A., Estruch, R., Salas-Salvadó, J., Corella, D., Covas, M. I., … & Pintó, X. (2013). Mediterranean dietary pattern and depression: the PREDIMED randomized trial. BMC medicine, 11(1), 208.

Thompson, N. J., Patel, A. H., Selwa, L. M., Stoll, S. C., Begley, C. E., Johnson, E. K., & Fraser, R. T. (2015). Expanding the efficacy of Project UPLIFT: Distance delivery of mindfulness-based depression prevention to people with epilepsy. Journal of consulting and clinical psychology, 83(2), 304.

Topper M, Emmelkamp PMG, Watkins E, Ehring T. Prevention of anxiety disorders and depression by targeting excessive worry and rumination in adolescents and young adults: A randomized controlled trial. Behav Res Ther [Internet]. 2017 Mar [cited 2017 Feb 21];90:123–36.

Van ‘t Veer-Tazelaar PJ, van Marwijk HWJ, van Oppen P, Nijpels G, van Hout HPJ, Cuijpers P, Stalman WAB, Beekman ATF (2006). Prevention of anxiety and depression in the age group of 75 years and over: a randomised controlled trial testing the feasibility and effectiveness of a generic stepped care programme among elderly community residents at high risk of developing anxiety and depression versus usual care. BMC Public Health, 6, 186 (18 July 2006).

Willemse GRWM, Smit F, Cuijpers P, Tiemens BG: Minimal contact psychotherapy for sub-threshold depression in primary care: a randomised trial. Br J Psychiatry 2004; 185: 416-421

Young JF, Mufson L, Davies M: Efficacy of Interpersonal Psychotherapy-Adolescent Skills Training: an indicated preventive intervention for depression. J Child Psychol Psychiatry 2006; 47: 1254-1262

Young, J. F., Mufson, L., & Gallop, R. (2010). Preventing depression: A randomized trial of interpersonal psychotherapy‐adolescent skills training. Depression and anxiety, 27(5), 426-433.